Table 1.
miRNA profiling studies in diabetic microvascular complications.
| DMC | Study design | Source | Number of ΔmiRNAs | Selected differentially expressed miRNA | Ref | |
|---|---|---|---|---|---|---|
| DR | STZ-DM rats versus controls | Retinas | Δ86 | ↑ 31, 31∗, 34b-3p, 34c, 184,199a, 200a, 200b, 205, 223, 335-3p, 378∗, 488, 574-3p ↓ 20b, 499, 690 (17 PCR-validated miRNAs) |
[22] | |
| REC | Δ120 | ↑ 15b, 19b, 21, 31, 132, 142-3p, 146a, 155, 339-5p, 342-3p, 450a ↓ 20b-5p, 29c, 181c, 136∗, 376c (16 PCR-validated miRNAs) |
||||
| db/db mice versus controls | Retinas | Δ6 | ↑ 21, 31, 132, 184, 379, 322 ↓ 29b, 294∗, 376b, 690, 712 (>2-fold increase) |
[41] | ||
| DM2 patients versus controls | REC | ↑ 60, ↓ 16 | ↑ 133 ↓ 10a, 10b, 15a (4 PCR-validated miRNAs) |
[21] | ||
|
| ||||||
| DSPN | STZ-DM mice versus controls | DRG | ↑ 74 ↓ 68 |
↓ let-7i, 103, 16, 107, 130a, 30a, 29a, 138, 27a, 27b, let7g, 30b, let7f, 34a, 338-3p ↑ 191, 466-5p, 149∗, 341∗ (>1.5 fold-change) |
[51] | |
| STZ-DM mice versus controls | Spinal dorsal horn | ↑ 21 ↓ 21 |
↑ 184-5p ↓190a-5p (2 PCR-validated miRNAs) |
[137] | ||
|
| ||||||
| DN | DN FSGS IgAN MPGN Controls |
Human glomeruli | DN: Δ18 FSGS: Δ12 IgAN: Δ2 MPGN: Δ17 versus controls |
DN versus controls: ↑ 29a, 23a, 214, 21, 5585, 589, 150, 4286 ↓ 486-3p, 486-5p, 1180, 4301, 30a-3p, 30c, 148a, 30a-5p, 3184, 423 DN versus FSGS: ↑ 24, 146a DN versus MPGN:↑ 146a, 146b; ↓ 671 |
[37] | |
| DM2 patients versus healthy controls | Kidney | ↑ 32 ↓ 39 |
↑ 146a, 155 (2 PCR-validated miRNAs) |
[28] | ||
| db/db mice versus controls | Glomeruli | ↓ 45 | ↓ 5 | ↓ 92a, 92b, 93, 140, 191 | [55] | |
| HG versus NG | Podocytes | ↓ 32 | ||||
| GEC | ↓ 86 | |||||
DMC: diabetic microvascular complications; DM: diabetes; DM2: type 2 diabetes; STZ-DM: streptozotocin-induced diabetes; DR: diabetic retinopathy; DN: diabetic nephropathy; DSPN: diabetic peripheral symmetric polyneuropathy; HG: high glucose; NG: normal glucose; FSGS: focal segmental glomerulosclerosis; MPGN: membranoproliferative glomerulonephritis; REC: retinal endothelial cells; GEC: glomerular endothelial cells; DRG: dorsal root ganglia; Δ: differentially expressed miRNAs. ∗miRNA nomenclature.