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. 2018 Mar 22;20:19. doi: 10.1186/s13058-018-0938-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a Hierarchical clustering analysis of all differentially expressed proteins (DEPs) (812 proteins at p ≤ 0.05 with ≥ 2 unique peptides). b Insulin signalling pathway significantly over-represented in DEPs between good and poor outcome groups (Fisher exact p = 0.015) using KEGG Pathway analysis with DAVID. Tabulation of gene names of the observed differentially expressed proteins constituent to the pathway presented. c MetaCore showed that glycolysis/gluconeogenesis was a significantly enriched process in the DEPs between good and poor outcome groups (FDR corrected p = 0.011). d Network analysis of differentially expressed proteins using Ingenuity Pathway Analysis showed participation of resistin in the small molecule biochemistry network (score = 23; focus molecules = 20)