Table 1.

Study; Country Study type; Setting; Conditions; Diagnosis tool; Number of participants; Age; and Sex

Author	Country	Study type	Setting	Conditions (%) Provided, whenever available, if an interventions was delivered to a mixed clinical group	Diagnosis tool	Number of participants	Age	Sex
Forsyth et al., 2009 [64]	Australia	Pilot (feasibility) RCT	Primary Care	a) Depression (51%) b) Anxiety (19%) c) Mixed anxiety-depression disorder (30%) Participants’ mean BMI = 29.7 kg/m2	The Depression Anxiety Stress Scale DASS-21	At baseline = 25; but only 18 patients completed an initial assessment At week 12 = 5	Age range: 19–73	At baseline: Male = 9 Female = 16
Mailey et al., 2010 [25]	USA	Pilot RCT	Community and University-based Healthcare Services	a) Depression b) Anxiety	The Beck’s Depression Inventory (BDI)	Intervention arm At baseline = 26 At week 10 = 23 Control arm At baseline = 25 At week 10 = 24	At baseline: Intervention & Control Arms = 25 yr (18–52 yr)	At baseline: The sample (in both study arms) was primary female (68.1%)
Oeland et al., 2010 [31]	Denmark	RCT	Primary Care	a) Mild-to-moderate depression (MMD) b) MMD recurrent c) Anxiety	The Hamilton Depression Rating Scale (HAM-D)	Intervention Arm At baseline: Total number of Pts = 27 [MMD (60%); MMD recurrent (18%); Anxiety (23%)] At week 32: Total number of Pts = 13 [condition-specific information - not provided] Control Arm Total number of Pts: 21 [MMD (43%); MMD recurrent (38%); Anxiety (20%)] At week 32: Total number of Pts = 15 [condition-specific information - not provided]	At baseline: Intervention arm = 36 yr (18–52) Control arm = 40 yr (20–67)	At baseline: Intervention arm = 85/15 Control arm = 67/33
Pentecost et al., 2015 [32]	UK	Pilot RCT	Primary Care: Improving Access to Psychological Therapies (IAPT) Services	a) Mild Depression b) Moderate Depression c) Severe Depression	The Clinical Interview Schedule - Revised (CIS-R) & the Patient Health Questionnaire-9 (PHQ-9)	Intervention 1 arm At baseline: (Behavioural activation plus physical activity promotion) Mild depression = 6 (20%) Moderate depression = 16 (53.3%) Severe depression = 8 (26.7%) At week 16: Mild depression = 4 (13.3) Moderate depression = 16 (53.3%) Severe depression = 10 (33.3%) Intervention 2 arm (Behavioural activation) At baseline: Mild depression = 2 (9.1%) Moderate depression = 2 (9.1%) Severe depression = 1 (4.5%) At week 16: Mild depression = 1 (4.8%) Moderate depression = 4 (19%) Severe depression = 3 (14.3%)	At baseline: Intervention 1 arm 18–30 yr, n = 6 31+ yr, n = 24 Intervention 2 arm 18–30 yr, n (%) = 6 31+ yr, n = 24	At baseline: Intervention 1 arm Male = 18 Female = 20 Intervention 2 arm Male = 13 Female = 17
Piette et al., 2011 [26]	USA	RCT	Various, a community-university-and VA healthcare system	Comorbid moderate depression (Beck Depression Inventory scores ≥14) & diabetes	The Beck’s Depression Inventory (BDI)	Intervention arm At baseline = 172 At 12 months = 145 Control arm At baseline = 167 At 12 months = 146	At baseline: Patients’ mean age was 56 yr	At baseline: Male = 49% Female = 51%
Suija et al., 2009 [27]	Estonia	RCT	Primary Care	Mild-to-moderate depression (MMD)	The Composite International Diagnostic Interview (CIDI)	Intervention arm (patients with depression) At baseline = 48 randomised; 16 agreed to participate in the study At week 24 = 4 Control arm (non-depressed patients) At baseline = 58 randomised; 5 agreed to participate in the study At week 24 = 5	At baseline: 18–29 yr, n = 7 40–59 yr, n = 5 ≥60 yr, n = 1	At baseline: Male = 1 Female = 15
Crone et al., 2008 [33]	UK	Quasi-experimental	Primary Care	Mental health group (4.6% of all study participants); this included: a) Depression (61%) b) Anxiety/loss of confidence (26%) c) Stress/tension (13%) Physical health: Cardio-vascular disease, overweight, obesity, diabetes, musculoskeletal health, unfit/sedentary, or other	No information given	At baseline: Mental health = 134 Physical health = 2500 At 12 week or programme completion: Mental health = 29 Physical health = 935	At baseline: Mental health group: 42 ± 14 yr Physical health group: 51 ± 14 yr	At baseline: Male = 36% Female = 64%
Duda et al., 2014 [28]	UK	RCT	Primary Care	Mental health group: a) Probable (Mild) Depression (18.9%) b) Probable anxiety (34.8%) Comorbidities: Two or more factors for coronary heart disease (CHD), overweight, obesity, other long term conditions (LTCs), asthma, bronchitis, diabetes, those for whom regular PA may prevent the onset of osteoporosis, those with borderline hypertension.	The Hospital Anxiety and Depression Scale (HADS)	Total No of participants: 347 (a sample of 494 participants was required to detect a difference in mean PA time across the intervention and control arms) Intervention arm At baseline = 184 At 6-month follow up = 82 Control arm At baseline = 163 At week = 92	At baseline: Intervention arm < 30 yr, n = 19 30–49 yr, n = 76 50–64 yr, n = 64 ≥65 yr, n = 25 Control arm < 30 yr, n = 11 30–49 yr, n = 77 50–64 yr, n = 50 ≥65 yr, n = 25	At baseline: Intervention arm Male = 45 (24.5%) Female = 139 (75.5%) Control arm Male = 49 (30.1%) Female = 114 (69.9%)
Littlecott et al., 2014 [29]	UK	RCT	Primary Care	Mental health (4%): a) Depression b) Anxiety Physical health: a) CHD risk factors Both: Comorbid mental health and physical health	The Hospital Anxiety and Depression Scale (HADS)	At baseline, 1080 participants were randomised to each trial arm Intervention arm At 12 months: Mental health =19 CHD risk = 362 Control arm At 12 months: Mental health = 13 CHD risk = 339	At baseline: 16–44 yr, n = 191 45–59 yr, n = 303 ≥60 yr, n 386 Condition-specific age data is not provided	At baseline: Male = 316 Female = 590 Condition-specific sex data is not provided
Pomp et al., 2013 [30]	Germany	Quasi-experimental	Orthopaedic rehabilitation	Depression (10%) Other health conditions - no information available	The Patient Health Questionnaire-9 (PHQ-9)	Intervention arm At baseline = 227 At week 6 = 132 Control arm At baseline = 279 At week 6 = 229	The authors state that the control and intervention arms did not differ in terms of sex and age. No further details are provided.	The authors state that the control and intervention arms did not differ in terms of sex and age. No further details are provided.