Table 2. Variables That Are Most Predictive of Cluster-Level Outcomes in Major Depressive Disorder.

Core Emotional Cluster	Atypical Cluster	Sleep/Insomnia Cluster
Baseline core symptoms	Baseline atypical symptomsa	Baseline sleep symptomsa
Employed?	QIDS hypersomniaa	Age
Initial HAM-D severitya	Employed?	Black/African American
QIDS psychomotor agitation	QIDS psychomotor agitation	Employed?
QIDS energy/fatigability	Anxious standing in long lines	QIDS psychomotor agitation
Family thinks patient has drug problem	Sexa	QIDS sleep-onset insomnia
Years of education	Baseline core symptoms	QIDS early-morning insomniaa
Black/African American	Marriage problems because of drinkinga	Frequent worrying about writing in public
Anxious about driving/riding in car	Thought might go crazy/lose control during anxiety attacka	Bothered by bodily aches and pains
Ever witnessed a traumatic event	Bothered by bodily aches and pains	Anxious about being in crowded places
HAM-D loss of insight	QIDS suicidal ideation	No. of previous depressive episodesa

Abbreviations: HAM-D, Hamilton Depression rating scale; QIDS, Quick Inventory of Depressive Symptomatology.

^aPredictors that were not among the top 25 predictors for any other cluster (ie, cluster-specific predictors).