Table 1.
Physicochemical properties of the CP-NIC conjugate.
| CP-polypeptide sequence | SKGPG(XGVPG)160WPC(GGC)7 |
| Guest residues (X) | V:A:G [1:8:7] |
| Molecular weight of CP (KDa) | 62.5 |
| 1Drugs per CP | 4 |
| 2Rh (nm) | 30.1 ± 10.4 |
| 2Rg (nm) | 81.5 ± 5.8% |
| 3Z (chains per nanoparticle) | 90 |
| ρ | 1.65 |
| MW (g/mol) | 5.83 × 106 ± 3.9% |
| CMC (μM) | 3.1 |
1
Drug molecules calculated from MALDI MS.
2
Rh determined by DLS at 25 °C in PBS. Mean ± %PD (n=3).
3
Aggregation number (Z): Number of CP-NIC molecules per nanoparticle, as determined by SLS.