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. 2018 Mar 2;12:119. doi: 10.3389/fnins.2018.00119

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Copyright © 2018 Borello, Berarducci, Delahaye, Price and Dehay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SP8 transcriptional regulation of Ccnd1 genomic regions bound by Sp8. Panels (A,C,E) show details of the Ccnd1 locus where the SP8 ChipSeq peak have been detected: (A) SP8 peak at the Ccnd1 Ex1 fragment; (C) SP8 peak at the Ccnd1 Ex5 fragment; (E) Sp8 peak at the Ccnd1 Ex2.3 fragment. 1: SP8 Chip input peaks, 2: SP8 Chip peaks, 3: H3K27ac Chip Input peaks, 4: H3K27ac Chip peaks, 5: CpG island, 6: Ccnd1 RefSeq gene model. For details refer to the legend of Figure 2. Panels (B,D,F) show the results of the luciferase assays performed with Ccnd1 Ex1 (B), Ccnd1 Ex2.3 (F), and Ccnd1 Ex5 (D) fragments. Statistical significance, ANOVA: ^*p < 0.05, ^**p < 0.01.