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. 2018 Feb 28;12:49. doi: 10.3389/fncel.2018.00049

Figure 6.

Figure 6

Caffeine or modafinil administration altered the morphology of astrocytes and microglia towards the resting state in rat hippocampus during SD. Representable image (intersection and segmented mask) of (A) normal and activated astrocyte; (B) resting, intermediate and activated stage microglial cell. Changes in the (C) soma density; (D) soma area; (E) sum inters; (F) mean inters; (G) ramification index; (H) astrocyte length of astrocytes in DG, CA1 and CA3 regions of the hippocampus. Changes in the (I) soma density; (J) soma area; (K) sum inters; (L) mean inters; (M) ramification index; (N) microglial length of microglia cells. *p < 0.05 when compared to control treated with vehicle; φp < 0.05 when compared to sleep deprived treated with vehicle. Two way ANOVA followed by Tukey post hoc test with multiple comparison was applied for statistical comparison between groups and for the graphical representation, values expressed mean percentage of Control ± SEM.