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. 2018 Mar 15;9:96. doi: 10.3389/fendo.2018.00096

Table 2.

Affected bones, fractures, and surgical operations in pediatric patients with polyostotic fibrous dysplasia (n = 16).

Patient number Age category (years)a Height SDSa Affected bones Craniofacial involvement Fractures Orthopedic (or other) surgery Orthopedic disabilities/problems Chronic pain/head aches
1 10–15 −0.5 Ribs, ilium, and femur + Fixation of femoral fracture

2 15–20 +0.2 Orbital and parietal bones +

3 15–20 −0.5 Pelvis and femur + Epiphysiodesis and spondylodesis Disabling deformity of pelvis and hip

4 10–15 −0.2 Orbital, maxillar, frontal, sphenoidal, temporal, mandibular bones, humerus, fibula, tibia, and femur + Stenosis of nervus opticus + Fixation of femoral fracture; osteotomy + Headaches

5 15–20 +0.4 Sphenoidal, frontal and orbital bones unilaterally + Stenosis of nervus opticus (Decompression of optic nerve) + Headaches

6 15–20 −1.7 Skull base, parietal, occipital, orbital, temporal, humerus, fibula, tibia, and femur; all unilaterally + + Fixation of femoral fracture times 3; correction of coxa valgus deformity + Headaches

7 15–20 +0.5 Occipital, parietal, maxillar, mandibular bones, humerus, radius, femur, and tibia + +

8 5–10 N/Ab Ceiling of orbita, maxillar, mandibular, frontal, ethmoidal, sphenoidal, temporal, occipital, and parietal bones, femur, tibia, and fibula + + Fixation of femoral neck bilaterally; osteotomy Severe scoliosis

9 15–20 +0.1 Sphenoidal, maxillar, and ceiling of orbita unilaterally; frontal bone, foramina optica bilaterally + Stenosis of nervus opticus + Headaches

10 15–20 −1.3 Skull base (mostly unilaterally): frontal, sphenoidal, orbital, maxillar, and temporal bones; pelvis, femur bilaterally + Stenosis of nervus opticus + Femoral osteosynthesis bilaterally Chronic pain

11 10–15 +1.6 Femur and fibula bilaterally; tibia, skull base (widely), mandibular, zygomatic, maxillar bones, humerus, and orbital bones + Stenosis of nervus opticus + Varus malalignment of hip Chronic pain

12 10–15 −0.3 Frontal, parietal, and ethmoidal bones, concha superior, sinus maxillaris unilaterally, and sinus ethmoidalis bilaterally + + (Skull operation)

13 10–15 +0.5 Maxillar and sphenoidal bones, fossa cranii media +

14 10–15 −1.3 Tibia (widely), fibula unilaterally +

15 5–10 +1.2 Pelvis, femur, tibia, talus, humerus, and radius + + Fixation of femur fracture with osteosynthesis; osteotomy

16 10–15 −0.1 Maxillar bone bilaterally + + Headaches

SDS, standard deviation score.

aAge and height SDS at last follow-up visit.

bHeight measure not possible; arm span used as a proxy for height.