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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Immunol. 2018 Apr 1;200(7):2235–2244. doi: 10.4049/jimmunol.1701704

FIGURE 2.

FIGURE 2

Development and homeostasis of iIEL subsets. Except for TCRγδ+ iIELs, all TCR+ (red font) iIEL develop in the thymus. All TCR− (blue font) iIELs develop extrathymically. Induced TCR+ iIEL follow a conventional thymic development and selection pathway, whereas natural CD8αα+TCRαβ + iIELs undergo agonist selection. iIELs require a variety of transcription factors for their development and function. Many TCR+ iIELs initiate CD8αα expression upon entry into the epithelium. The development, maintenance and homeostasis of iIELs requires a variety of factors, as indicated.