Table 2.

Amino acid binding in the docked structure with different proteins

	GLY	PRO	TRP	THR	ASN	GLU	GLN	LYS	SER	ASP	HIS	ILE	LEU	VAL	ARG	PHE	ALA	CYS	TYR
ICAM-1	+	++	+++	++	++	+	+
CCL-20				+				++	+	+	++	+
IL-8						++	++	+					++	+
NF-kB	++	++						+			+		+		++	+
P-38	+					+	++	+		+		++		+	++	+	+
PIGF	+			+							+		++		+			++++
CXCL-1		+				+		+				+
CXCL-5		+			+		+	+				+	++++	+			+
CD 35		+++++	+	+				++	+			+		+				+	+
MMP-9		+					+			++					++	+			++
Total frequency	5	12	4	5	3	5	7	9	2	4	4	6	9	4	7	3	2	5	3

Note: +, number of times TNP interacts with the respective amino acid.

Abbreviations: CCL-20, chemokine ligand 20; CD, cluster of differentiation 35; CXCL, C–X–C motif chemokine ligand; ICAM-1, intercellular adhesion molecule 1; IL-8, interleukin 8; MMP-9, matrix metallopeptidase 9; NF-kB, nuclear factor kappa B; PIGF, placental growth factor; TNP, titanium dioxide nanoparticle.