Clinical activity	Trigger	Which patients to search	Importance of trigger
Prescribing	‘Triple threat’	People >65 years co-prescribed NSAIDs, ACEIs/ARBs, and diuretics	This combination of medications is responsible for significant numbers of medication-related hospital admissions as it can put patients at increased risk of acute kidney injury
	Heart failure and NSAIDs	People with coded heart failure prescribed NSAIDs as repeat medication	NSAIDs and risk of worsening heart failure
Results handling	>75 years with low haemoglobin or ferritin	People >75 years old with haemoglobin <100 g/L or ferritin <15 ng/ml	To identify patients with occult blood loss
	Falling eGFR	People with a drop of ≥10 ml/minute in eGFR compared with previous result	To identify patients at risk of progressive CKD
Uncoded diagnoses	Uncoded CKD	People with eGFR <60 ml/minute but not coded as CKD	Uncoded CKD is associated with suboptimal primary care management and increased prescribing risk

ACEI/ARB = angiotensin-converting enzyme inhibitor/angiotensin receptor blockers. CKD = chronic kidney disease. eGFR = estimated glomerular filtration rate. NSAID = non-steroidal anti-inflammatory drug.