Table 1.
Independent and dependent variables
| Batch code | Independent variables
|
Dependent variables
|
OD | |||
|---|---|---|---|---|---|---|
| X1 | X2 | Average particle size (n=3) (Y1) | % Drug entrapment efficiency (n=3) (Y2) | Drug loading (Y3) | ||
| P1 | −1 | −1 | 188.9±3.6 | 91.24±2.6 | 40.61 | 0.7854 |
| P2 | −1 | 0 | 198.1±2.38 | 88.19±0.6 | 39.81 | 0.7137 |
| P3 | −1 | +1 | 272.4±2.98 | 88.34±0.20 | 30.64 | 0.197 |
| P4 | 0 | −1 | 174.2±12.10 | 84.3±1.42 | 55.84 | 0.997 |
| P5 | 0 | 0 | 192.5±0.92 | 83.41±0.87 | 29.43 | 0.5206 |
| P6 | 0 | +1 | 251.17±3.45 | 81.95±0.57 | 23.50 | 0.2415 |
| P7 | +1 | −1 | 180.33±10.69 | 77.50±0.89 | 36.75 | 0.5597 |
| P8 | +1 | 0 | 195.9±0.7 | 67.75±3.93 | 25.30 | 0 |
| P9 | +1 | +1 | 275.6±3.4 | 67.95±2.4 | 20.31 | 0 |
Notes: X1, volume of the external phase of the secondary emulsion; X2, amount of the polymer. Bold data indicates nanoparticles with the highest overall desirability.
Abbreviation: OD, overall desirability.