Figure 1. Pedigree charts.
The age at examination of each individual sequenced in this study is given beneath the identifier number. Individuals diagnosed with AD are indicated as affected (dark gray), individuals with AD-like symptoms reported by their family members are indicated in light gray. (A) Pedigree of family 1. The genotypes are wild type (G/G) or the alteration (G/A) that causes the ABCA7 missense mutation. (B) Pedigree of family 2. The genotypes are wild type (T/T) or the alteration (T/del) that causes the ABCA7 frameshift mutation.