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(A) The maximum LOD score (1.8) over the whole chromosome is seen in the region containing ABCA7. (B) Linkage analysis of the ABCA7 region on chromosome 19. The maximal LOD score (1.8) could be found on chromosome 19 in the region from 257,507 to 3,909,104 suggesting linkage, the region in red spans the gene ABCA7. Of the combined LOD score of 1.8 in the region spanning ABCA7, family 1 and family 2 contributed LOD scores of 1.2 and 0.6, respectively.
