Figure 3.

Schematic representation of possible SARAH-mediated intermolecular interactions. (A) MST2 (blue) homodimers can be subject to autophosphorylation mediated by an active loop (green). (B) RASSFn scaffolding proteins (red) can form competitively heterodimers with MST2 SARAH domains. (C) MST2 SARAH domains can interact with other binding domains from partners such as RAF. (D) Owing to its large and flexible linker, MST2 may present self-interactions of its SARAH and catalytic domains. (E) MST2 SARAH homodimers (blue) may be affected by tertiary (e.g. RASSFn) SARAH domains that could modulate the MST2 homo-interactions. A colour version of this figure is available at BIB online: http://bib.oxfordjournals.org.