Table 1.
Systemic characteristics and cardiac function and structure (mean ± SEM) of normal ( n = 7), mild ( n = 5), and moderate ( n = 5) renovascular hypertension (HTN) pigs
| Normal | Mild HTN | Moderate HTN | |
|---|---|---|---|
| Body weight (kg) | 47.7±1.3 | 46.2±2.7 | 49.8±3.0 |
| Degree of stenosis (%) | — | 73±6 | 98±2 † |
| MAP (mm Hg) | 87.1±2.1 | 93.1±2.0* | 131.4±6.7* ,† |
| Plasma creatinine (mg/dl) | 1.2±0.1 | 1.7±0.1* | 1.6±0.1* |
| PRA (ng/ml/h) | 0.2±0.1 | 0.2±0.1 | 10.6±4.8* |
| Plasma aldosterone (pg/ml) | 555.6±33.7 | 519.2±42.3 | 1,044.5±44.5* |
| E/A ratio | 1.4±0.1 | 0.8±0.1* | 0.9±0.1* |
| LVEDV (ml) | 1.9±0.1 | 1.8±0.1 | 1.7±0.1 |
| Stroke volume (ml) | 49.9±1.2 | 54.7±3.5 | 54.5±5.0 |
| Cardiac output (l/min) | 5.3±0.6 | 5.2±0.5 | 4.5±0.5 |
| Ejection fraction (%) | 55±3.0 | 56±4.0 | 63±8.0 |
Abbreviations: LVEDV, left ventricular end-diastolic volume; MAP, mean arterial pressure; PRA, plasma renin activity. * P < 0.05 vs. normal; †P < 0.05 vs. mild HTN.