Table 6.

Prevalence and mutation profile in rpoB, katG, inhA and ahpC genes in MDR strains in Kyrgyzstan

MDR -TB				N = 157	%
RIF-resistance	INH-resistance
rpoB	katG	inhA	ahpC
Ser531 → Leu	Ser315 → Thr	–	–	79	50.3
Ser531 → Leu	Ser315 → Thr	InhA_T15	–	3	1.9
Ser531 → Leu	Ser315 → Asn	–	–	5	3.2
Ser531 → Leu	Ser315 → Arg	–	–	3	1.9
His526 → Arg	Ser315 → Thr	–	–	7	4.5
His526 → Asp	Ser315 → Thr	–	–	6	3.8
His526 → Tyr	Ser315 → Thr	InhA_T15	–	14	9.0
His526 → Leu	Ser315 → Gly	–	–	1	0.6
His526 → Leu	–	InhA_T15	–	2	1.3
His526 → Pro	–	inhA_T15	–	1	0.6
His526 → Asn	–	inhA_T15	–	1	0.6
Asp516 → Tyr	Ser315 → Thr	–	–	13	8.3
Asp516 → Val	Ser315 → Thr	–	–	2	1.3
Leu511 → Pro	Ser315 → Thr	–	–	12	7.6
Leu533 → Pro	Ser315 → Thr	–	–	8	5.1