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. 2018 Mar 22;16:27. doi: 10.1186/s12951-018-0357-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effect of HAp on coagulation: APTT, PT and Plasma recalcification time (1–10 mg/mL HAp). Both particles had minimal effects on blood compatibility assays, but HAp2 revealed a trend for decreased values at 10 mg/mL. *Significantly different from negative control; p ≤ 0.05