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. 2018 Mar 22;16:27. doi: 10.1186/s12951-018-0357-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Gene expression of vWF, CE Cad and CD31 by human endothelial cells exposed to HA particles (a) and CLSM images of cells stained for CD31 (green) and nucleus (red) (b); HA particles: 50 μg/mL. HAp2 decreased the expression of VE Cad and CD31 genes, and affected the immunolabeling of CD31. *Significantly different from control (absence of particles); p ≤ 0.05