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. 2018 Mar 22;20:22. doi: 10.1186/s13058-018-0949-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Identification of broad-spectrum phosphatase and tensin homolog-synthetic sick/lethal (PTEN-SSL) genes. a The p values from the one-sided Wilcoxon rank-sum test for the hypothesis that PTEN- cell lines are more sensitive (lower ATARiS scores) to knockdown of each gene compared to PTEN+ cell lines. Each bar represents one of 727 genes in the secondary screen with computed ATARiS gene solutions. Possible broad-spectrum PTEN-SSL genes were selected using p < 0.05 (not corrected for multiple testing) and are shown as red bars. b Heat map visualization of the sensitivity (ATARiS scores) of individual cell lines in response to on-target mRNA knockdown of 24 possible broad-spectrum PTEN-SSL genes selected in the secondary screen (red region in a)