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Synthesis of the natural product 6-Br-8-keto-conicamin (2a) and nine key analogs 3, 8, and 10–16 for in vitro cytotoxicity screening against the PANC-1 tumor cell line. Following the synthetic route to 11 from 5 enabled facile differentiation between the 5- and 6-bromo isomers 11 and 12 synthesized from 10. The spectral and biological properties of 2a, 11, or 14 derived from 5 were equivalent to those derived from 10.
