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. 2018 Mar 22;13(3):e0193499. doi: 10.1371/journal.pone.0193499

Fig 4. Quantitative comparison of differentially expressed transcripts and the biological responses that are significantly enriched in mast cells by AgNPs.

Fig 4

(A) Venn diagram showing the number of differentially expressed (DE) genes produced in response to DNP treatment (black) and AgNP treatment (grey) with a combined total of 3890 genes. (B) Heat map of the relative expression of 85 DE genes (FDR≤0.05) following AgNP exposure in the low responder (LP/J) and high responder strain (C57BL/6J). Expression patterns for individual genes are in rows. The color represents the direction of difference in expression with red indicating increased expression and green indicated decreased expression after treatment; The intensity of the color represents the magnitude of difference in expression (log2 scale) between AgNP treated cells and non-treated cells. (C) Gene ontology (GO) categories overrepresented in the 34 AgNP-responsive gene set were assessed using Pantherdb.org. GO categories are ranked by number of genes, listing the number of AgNP-responsive genes in each category (white bar) verses the number of genes expected in each category (black bar). Significance was set at p≤0.05 with a fold enrichment cutoff of ≥5. RTK, receptor tyrosine kinase; MAPK, mitogen-activated protein kinase.