Table 1. Chromosomal loci significantly associated with mast cell degranulation by AgNP or DNP and genes residing in each locus.
| Treatment | Chr. | QTL interval (Mb) | Peak marker | Location (Mb) | Adjusted p-value | # of genes in region a | Genes closest to peak markerb |
|---|---|---|---|---|---|---|---|
| AgNP | 1 | 58.12–59.13 | rs32615733 | 58.52 | 4.31 × 10−3 | 13 | NDUFB359, NIF3L159, FAM126B59, BZW159, CASP859, CFLAR59, CLK159, PPIL359, TRAK247-49, STRADB, MPP4, ORC2 |
| 2 | 84.84–106.38 | rs27379157 | 96.49 | 8.53 × 10−3 | 79 | PRDM11, CREB3L1, TRAF647-49, LDLRAD354, CD8250, API5, TTC17, HSD17B12, ALKBH3, ACCS, EXT2, TRP53I11, MAPK8IP1, SLC35C1, CHST1, PEX16, PHF21A, CRY2 | |
| 18 | 30.42–50.19 | rs30077945 | 41.12 | 4.55 × 10−6 | 100 | GNPDA1, RNF14, NDFIP150, LARS, TCERG, ARHGAP26, PRELID2, SH3RF2, YIPF5, RBM27, EIF3J2, NR3C1, HDAC3, ARAP3, YTHDC2, PCDH1 | |
| DNP | 9 | 5.79–7.77 | rs37375155 | 6.1 | 1.29 × 10−2 | 9 | DYNC2H1, MMP8, MMP7, DCUN1D552, MMP12, MMP13, TMEM123, MMP27, GM10709 |
a Indicates # of genes residing in the locus that were also identified in RNA-sequencing analysis.
b Protein-coding genes (<20) closest to each peak marker residing in the locus. Proposed candidate genes identified in other GWAS studies are bold and genes overlapping with peak marker are underlined.
Chr., chromosome; AgNP, silver nanoparticles; DNP, dinitrophenyl.