Table 5. Known-groups validity: FLU-PRO scores by patient global rating of disease severity, Day 1.

	Patient Global Rating of Flu Severity
	No/Mild		Severe and
	Symptoms (N = 81)	Moderate (N = 77)	Very Severe (N = 60)
Scale	Mean (SD)	Mean (SD)	Mean (SD)	F Value (p-value)1	Pairwise Comparisons: No/Mild vs Moderate (p-value)	Pairwise Comparisons: No/Mild vs Severe/Very Severe (p-value)	Pairwise Comparisons: Moderate vs Severe/Very Severe (p-value)
Nose	0.89 (0.74)	1.65 (0.98)	2.00 (1.09)	26.9***	p<0.001	p<0.001	NS
Throat	0.97 (0.98)	1.48 (0.99)	2.41 (1.21)	32.4***	p<0.05	p<0.001	p<0.001
Eyes	0.37 (0.52)	1.04 (0.84)	1.48 (1.18)	30.7***	p<0.001	p<0.001	p<0.05
Chest/Respiratory	1.14 (0.73)	1.42 (0.69)	1.79 (0.93)	12.0***	NS	p<0.001	p<0.05
Gastrointestinal	0.32 (0.61)	0.38 (0.53)	0.72 (0.89)	6.9**	NS	p<0.01	p<0.05
Body/Systemic	0.83 (0.65)	1.40 (0.71)	2.15 (0.75)	62.2***	p<0.001	p<0.001	p<0.001
Total Score	0.81 (0.45)	1.28 (0.48)	1.84 (0.49)	81.7***	p<0.001	p<0.001	p<0.001

¹p values are: **<0.01, ***<0.001.

Abbreviations: SD = Standard Deviation; NS = Non-significant