Table 6. Responsiveness of FLU-PRO by patient return to usual health (N = 169)¹ and usual activities (N = 117)², Day 1 to Day 7.

	Responders3			Non-Responders
Scale	Day 1 Mean (SD)	Day 7 Mean (SD)	Change Score LSMean (SDerr)	Day 1 Mean (SD)	Day 7 Mean (SD)	Change Score LSMean (SDerr)	p-value4
Nose
Usual Health	1.5 (1.0)	0.5 (0.5)	1.0 (0.1)	1.4 (1.0)	0.8 (0.7)	0.7 (0.1)	0.0003
Usual Activities	1.6 (1.1)	0.7 (0.7)	0.7 (0.1)	0.9 (0.8)	0.5 (0.6)	0.7 (0.1)	0.8751
Throat
Usual Health	1.5 (1.1)	0.3 (0.5)	1.2 (0.1)	1.7 (1.3)	0.7 (0.8)	0.9 (0.1)	0.0029
Usual Activities	1.8 (1.2)	0.5 (0.7)	1.1 (0.1)	1.1 (1.2)	0.5 (0.9)	0.9 (0.1)	0.1351
Eyes
Usual Health	0.9 (1.1)	0.1 (0.4)	0.7 (0.1)	0.9 (0.9)	0.3 (0.6)	0.6 (0.0)	0.1202
Usual Activities	1.0 (1.1)	0.2 (0.5)	0.7 (0.1)	0.6 (0.9)	0.2 (0.6)	0.6 (0.1)	0.0919
Chest/Respiratory
Usual Health	1.3 (0.7)	0.5 (0.6)	0.9 (0.1)	1.5 (0.8)	1.0 (0.7)	0.5 (0.1)	< .0001
Usual Activities	1.4 (0.8)	0.8 (0.7)	0.7 (0.1)	1.6 (0.8)	0.8 (0.8)	0.7 (0.1)	0.6139
Gastrointestinal
Usual Health	0.4 (0.7)	0.1 (0.3)	0.3 (0.0)	0.4 (0.6)	0.2 (0.4)	0.2 (0.0)	0.0585
Usual Activities	0.4 (0.7)	0.1 (0.2)	0.4 (0.0)	0.4 (0.6)	0.2 (0.5)	0.3 (0.0)	0.0777
Body/Systemic
Usual Health	1.3 (0.9)	0.2 (0.3)	1.2 (0.1)	1.4 (0.9)	0.5 (0.5)	0.9 (0.0)	< .0001
Usual Activities	1.6 (0.9)	0.3 (0.4)	1.2 (0.0)	1.1 (0.9)	0.5 (0.5)	0.9 (0.1)	0.0004
Total Score
Usual Health	1.2 (0.6)	0.3 (0.3)	0.9 (0.0)	1.3 (0.6)	0.6 (0.5)	0.7 (0.0)	< .0001
Usual Activities	1.4 (0.6)	0.5 (0.4)	0.9 (0.0)	1.1 (0.6)	0.5 (0.5)	0.7 (0.1)	0.0064

¹Responders: N = 64; Non-responders: N = 105

²Responders: N = 69; Non-responders: N = 48

³Responders are defined as patients responding that they have returned to their usual health or usual activities at Day 7.

⁴Analysis of covariance was used to compare changes in FLU-PRO scores at day 7 in responders and non-responders, adjusting for day 1 scores.