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. 2018 Mar 22;13(3):e0194530. doi: 10.1371/journal.pone.0194530

Table 4. The 9 top affected cellular pathways influenced from the 29 microRNAs of the normal-severe comparison.

BIOCARTA Term Genes ID (ENTREZ) Fold Enrichment FDR p-value
1 h_tnfr1Pathway:TNFR1 Signaling Pathway 9530, 5599, 4214, 7124, 5058, 6885, 9731, 836, 4000, 4001, 835, 1676, 1677, 7186, 84823, 142 2.526724976 3.63E-04
2 h_tgfbPathway:TGF-beta signaling pathway 7040, 2033, 4088, 4089, 324, 6498, 7048, 6885, 9372, 4092, 999, 4087 2.992174313 4.54E-04
3 h_g1Pathway:Cell Cycle: G1/S Check Point 595, 7040, 1021, 993, 7027, 472, 4088, 2932, 1017, 4089, 1027, 1026, 898, 7157, 983 2.368804665 0.001372642
4 h_cellcyclePathway:Cyclins and Cell Cycle Regulation 595, 7027, 1017, 1027, 1026, 983, 1021, 993, 894, 5933, 891, 898, 896 2.463556851 0.002255077
5 h_il2rbPathway:IL-2 Receptor Beta Chain in T cell Activation 3265, 596, 6464, 5478, 8651, 3716, 207, 6198, 1399, 2885, 3667, 6777, 9021, 2353, 22806, 4609, 5594 2.065111759 0.003326904
6 h_mapkPathway:MAPKinase Signaling Pathway 4149, 4209, 3265, 5599, 1432, 8550, 6464, 2872, 7040, 7186, 4214, 673, 9252, 4215, 4293, 5058, 6885, 1326, 1385, 6667, 6197, 6198, 2885, 5597, 4790, 2353, 5598, 5879, 4609, 5594 1.633658389 0.004199785
7 h_nfatPathway:NFAT and Hypertrophy of the heart (Transcription in the broken heart) 811, 3265, 2147, 5599, 805, 58, 9421, 1432, 801, 4775, 2932, 207, 5532, 1906, 4620, 6198, 5573, 808, 4773, 1482, 5594 1.842403628 0.004474806
8 h_raccycdPathway:Influence of Ras and Rho proteins on G1 to S Transition 595, 3265, 7027, 1017, 5058, 1027, 1026, 207, 1021, 4790, 898, 5879, 5594 2.281071159 0.00499535
9 h_pyk2Pathway:Links between Pyk2 and Map Kinases 3265, 805, 1399, 5599, 4214, 1432, 2885, 6464, 801, 808, 5058, 5879, 5594 2.199604332 0.007120062