Fig 9. The Cis4/Zrg17 heterodimer and Zhf1 have complementary roles in transporting zinc out of the cytosol into the secretory pathway.

When intracellular zinc levels are low, the Cis4/Zrg17 heterodimer transports zinc out of the cell into the secretory pathway (left panel). When zinc is not limiting, Zhf1 plays the primary role in transporting zinc out of the cytosol into cellular zinc stores (right panel). See text for further details.