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. Author manuscript; available in PMC: 2018 Mar 22.
Published in final edited form as: Semin Liver Dis. 2018 Feb 22;38(1):73–86. doi: 10.1055/s-0038-1629924

Figure 3.

Figure 3

Although the RIPKs are most known in the context of necroptosis they are multifunctional proteins. The kinase activity of RIPK1 mediates apoptosis and necroptosis while its scaffolding activity enables NFκB activation, inflammation and cell survival. RIPK3’s necroptosis independent roles include activation of cytokine secretion in certain models and inflammasome activation via caspase-8. Both RIPK1 and RIPK3 have been implicated in activation the NLRP3 inflammasome pathway.