Table 2.
Association between variability in HbA1c and GDS
| HbA1c-SD | IRR (95% CI) | P value |
|---|---|---|
| Overall (n = 837) | ||
| Model A | 1.20 (1.001–1.44) | 0.0485* |
| Model B | 1.22 (1.02–1.47) | 0.0285* |
| Model C | 1.29 (1.07–1.55) | 0.0078* |
| Model D | 1.24 (1.02–1.51) | 0.0318* |
| Model E | 1.33 (1.04–1.70) | 0.0230* |
| Model F | 1.31 (1.03–1.67) | 0.0273* |
| Sample stratified by mean HbA1c ≤7 (n = 555) | ||
| Model A | 1.17 (0.82–1.67) | 0.3939 |
| Model B | 1.18 (0.82–1.68) | 0.3728 |
| Model C | 1.31 (0.90–1.89) | 0.1550 |
| Model D | 1.26 (0.86–1.83) | 0.2341 |
| Model E | 1.30 (0.87–1.93) | 0.1979 |
| Model F | 1.30 (0.88–1.92) | 0.1943 |
| Sample stratified by mean HbA1c >7 (n = 282) | ||
| Model A | 1.22 (0.93–1.61) | 0.1516 |
| Model B | 1.30 (0.98–1.71) | 0.0650 |
| Model C | 1.41 (1.07–1.86) | 0.0139* |
| Model D | 1.40 (1.06–1.86) | 0.0185* |
| Model E | 1.41 (1.02–1.94) | 0.0351* |
| Model F | 1.41 (1.03–1.93) | 0.0331* |
IRR (95% CI) data were estimated using a negative binomial regression modeling score for the entire sample (n = 837) and stratified by mean HbA1c. Model A was unadjusted; model B was adjusted for age; model C was adjusted for age, years in the registry, years of education, and sex; model D was adjusted for age, years in the registry, years of education, sex, total cholesterol, systolic blood pressure, diastolic blood pressure, glomerular filtration rate (GFR), HDL, LDL, and diabetes medication group; model E was adjusted for age, years in the registry, years of education, sex, total cholesterol, systolic blood pressure, diastolic blood pressure, GFR, diabetes medication group, HDL, LDL, and mean HbA1c; and model F was adjusted for age, years in the registry, years of education, sex, total cholesterol, systolic blood pressure, diastolic blood pressure, GFR, diabetes medication group, mean HbA1c, HDL, LDL, and MMSE total score.
*Indicates statistical significance.