Figure 10.

hUTC transplantation preserves MG morphology and attenuates reactivity. A, Representative images of the MG labeled for GS (green) and SOX9 (red) from LE (control), RCS+BSS, and RCS+hUTC P21 and P60 retinae on P95. Percentages of (B) OPL and (C) IPL area covered by GS⁺ processes were increased following hUTC transplantation in the RCS rat. The number of SOX9⁺ cell bodies (D) distance between SOX9 cell bodies (E) were decreased in RCS rat with hUTC transplantation, suggesting reduced proliferative change of MG. F, Representative images of the MG labeled for GS (green) and GFAP (red) from LE (control), RCS+BSS, and RCS+hUTC P21 and P60 retinas on P95 demonstrate a sharply reduced reactive glial phenotype in the RCS+hUTC P21 and P60. Data were obtained from a minimum of 3 animals of either sex and expressed as mean ± SEM. *p < 0.05, ***p < 0.0001.