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. 2018 Mar 21;38(12):2923–2943. doi: 10.1523/JNEUROSCI.1532-17.2018

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Figure 2. — RCS PR loss begins between P21 and P30, and P21 hUTC injection preserves RCS PRs. Representative images of retinal sections stained with TUNEL (green) revealing apoptotic PRs in DAPI-counterstained (blue) sections at (A) P21, (B) P30, and (C) P60. D, Quantitative analysis of relative ONL thickness of RCS normalized to age-matched controls (LE) showed significant PR loss between P21 and P30. E, Subretinal hUTC injection delayed PR loss in the RCS rat as demonstrated by increased ONL thickness and decreased TUNEL-positive PRs (green) in RCS+hUTC P21 and P60 compared with RCS+BSS. F, Quantification of the relative change in ONL thickness. G, Quantification of TUNEL-positive PR density in ONL. Data were obtained from a minimum of 3 animals of either sex and expressed as mean ± SEM. *p < 0.05, ***p < 0.0001.