Fig. 4.

Functional association between mutp53 and mevalonate pathway-associated oncogenic proteins (Ras, RhoA, YAP/TAZ). Activated mevalonate pathway promotes prenylation and activities of Ras and RhoA, leading to their translocation into the plasma membrane and activation of the ERK and YAP/TAZ signaling pathways, respectively. Nuclear translocated ERK and YAP/TAZ promote transcription of downstream target genes involved in cancer cell proliferation and migration. Additionally, mutp53 increases activities of Ras, RhoA, and YAP/TAZ signaling through protein-protein interactions (BTG2, NY-F) and enhancing recycling of integrins/EGFR.