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A model of the involvement of SUMO and HDAC4 in the repression of Notch1 target gene expression. In the absence of SUMO, NICD binds to CSL leading to the recruitment of MAML and consequent activation of specific Notch target genes. Recruitment of HDAC4 to the NICD/CSL/MAML transcriptional complex by sumoylated NICD promotes HDAC4-mediated transcriptional repression
