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editorial

. 2018 Feb 27;25(4):637–639. doi: 10.1038/s41418-018-0062-2

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© ADMC Associazione Differenziamento e Morte Cellulare 2018

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Fig. 1 — ROS and p53 determine the differentiation routes of MSCs. Hyperactivation of p53 drives mitochondrial ROS production and adipocyte differentiation. p53 functions as an antioxidant under physiological condition or mild stress. MSCs are favored to differentiate into osteoblasts when p53 is absent or functionally compromised