Table 2. Selecting antimalarial drugs for specific regions of drug resistance.
| Area/region (6,48-50) | Drugs of choice |
|---|---|
|
Chloroquine-sensitive regions: Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China |
Chloroquine (Aralen®) Hydroxychloroquine (Plaquenil®) is an acceptable equivalent alternative (51), as are the three drugs used in chloroquine-resistant areas (see below). |
|
Chloroquine-resistant regions: Most of sub-Saharan Africa, South America, Oceania and Asia. See below for regions that are both chloroquine- and mefloquine-resistant. |
Atovaquone-proguanil (41,42,44-47,52) Doxycycline (41,42,44-47,52) Mefloquine (41,42,44-47,52) |
|
Chloroquine- and mefloquine-resistant regions: Various countries in Asia, Africa and the Amazon basin. However, it is a significant problem only in rural, wooded regions where Thailand borders with Myanmar (Burma), Cambodia and Laos, and in southern Vietnam. |
Atovaquone-proguanil (44,53,54) Doxycycline (44,53,54) |