Table.
Main characteristics of the 29 patients and susceptibility testing results of the outbreak multidrug-resistant tuberculosis isolates
| Sex | Age* | Country of diagnosis | Country where journey started | Month of diagnosis† | Site of disease | Microscopy result‡ | FASTQ accession number |
Phenotypic drug susceptibility testing results (critical concentration testing) |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INH | RIF | EMB | PZA§ | SM | MOX | OFL | AMI | KAN | CAP | ETH | PTH | CS | PAS | BDQ | DLM | LIN | |||||||||
| AT1 | Male | Child | Austria | Somalia | February, 2016 | Pulmonary | Negative | ERS1927711 | R | R | S | R | S | S | S | S | S | R | S | S | S | S | S | S | S |
| AT2 | Male | Adult | Austria | Somalia | September, 2016 | Pulmonary | Negative | ERS1927712 | R | R | S | R | S | S | S | S | S | R | S | S | S | S | S | S | S |
| DE1 | Male | Child | Germany | Somalia | March, 2016 | Pulmonary | Negative | ERS1927720 | R | R | S | R | S | S | NE | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE2 | Male | Child | Germany | Somalia | March, 2016 | Pulmonary | Negative | ERS1927721 | R | R | S | R | NE | NE | S | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE3 | Female | Adult | Germany | Somalia | March, 2016 | Pulmonary | Negative | ERS1927722 | R | R | S | R | S | S | NE | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE4 | Male | Child | Germany | Somalia | March, 2016 | Pulmonary | Positive | ERS1927723 | R | R | S | R | S | NE | S | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE5 | Male | Adult | Germany | Somalia | July, 2016 | Pulmonary | Negative | ERS1927724 | R | R | S | R | NE | NE | S | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE6 | Male | Adult | Germany | Somalia | August, 2016 | Pulmonary | Negative | ERS1927725 | R | R | S | R | S | NE | S | S | S | R | NE | NE | NE | NE | NE | NE | NE |
| DE7 | Male | Adult | Germany | Somalia | November, 2016 | Pulmonary | Positive | ERS1927726 | R | R | R | R | S | S | S | S | S | R | NE | NE | NE | NE | NE | NE | NE |
| DE8 | Male | Child | Germany | Somalia | September, 2016 | Pulmonary | Positive | ERS1927727 | R | R | NE | R | NE | NE | NE | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE9 | Male | Child | Germany | Somalia | May, 2016 | Pulmonary | Negative | ERS1927728 | R | R | R | R | S | S | S | S | S | R | NE | NE | NE | NE | NE | NE | NE |
| DE10 | Male | Adult | Germany | Somalia | March, 2016 | Pulmonary | Negative | ERS1927715 | R | R | NE | R | S | S | S | S | S | R | NE | NE | NE | NE | NE | NE | NE |
| DE11 | Male | Child | Germany | Somalia | May, 2016 | Pulmonary | Negative | ERS1927716 | R | R | R | R | NE | NE | NE | S | R | NE | NE | NE | NE | NE | NE | NE | |
| DE12 | Male | Adult | Germany | Eritrea | November, 2016 | Pulmonary | Negative | ERS1927717 | R | R | R | R | S | S | S | S | S | R | NE | NE | NE | NE | NE | NE | NE |
| DE13 | Female | Child | Germany | Somalia | December, 2016 | Pulmonary | Negative | ERS1927718 | R | R | NE | R | NE | NE | NE | S | NE | R | NE | NE | NE | NE | NE | NE | NE |
| DE14 | Male | Adult | Germany | Somalia | November, 2016 | Pulmonary | Positive | ERS1927719 | R | R | R | R | S | S | S | S | S | R | NE | NE | NE | NE | NE | NE | NE |
| FI1 | Male | Adult | Finland | Eritrea | October, 2016 | Pleural | Negative | ERS1927735 | R | R | NE | NE | S | S | S | S | S | R | S | NE | NE | NE | NE | NE | NE |
| FR1 | Male | Adult | France | Somalia | April, 2016 | Pulmonary | Negative | ERS1927739 | R | R | NE | NE | S | S | S | S | S | R | S | NE | NE | NE | S | NE | NE |
| FR2 | Male | Adult | France | Sudan | October, 2016 | Pulmonary | Positive | ERS1927740 | R | R | NE | NE | S | S | S | S | S | R | S | NE | NE | NE | S | NE | NE |
| SE1 | Female | Child | Sweden | Somalia | August, 2016 | Pulmonary | Negative | ERS1927768 | R | R | NE | NE | NE | S | S | S | S | R | S | NE | NE | NE | NE | NE | NE |
| SW1 | Male | Adult | Switzerland | Somalia | December, 2015 | Intrathoracic lymph nodes | Negative | ERS1927751 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW2 | Male | Adult | Switzerland | Somalia | April, 2016 | Pulmonary | Negative | ERS1927752 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW3 | Male | Child | Switzerland | Somalia | May, 2016 | Pulmonary | Positive | ERS1927753 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW4 | Male | Adult | Switzerland | Eritrea | May, 2016 | Pulmonary | Positive | ERS1927754 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW5 | Male | Child | Switzerland | Ethiopia | June, 2016 | Pulmonary | Negative | ERS1927755 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW6 | Male | Adult | Switzerland | Somalia | April, 2016 | Pulmonary | Positive | ERS1927756 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW7 | Male | Adult | Switzerland | Ethiopia | August, 2016 | Pulmonary | Negative | ERS1927757 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| SW8 | Male | Adult | Switzerland | Djibouti | September, 2016 | Pleural | Negative | ERS1927758 | R | R | S | R | S | S | NE | S | S | R | S | NE | S | S | S | S | S |
| UK1 | Male | Adult | UK | Sudan | April, 2017 | Spinal | Unknown | ERS1927759 | R | R | R | S | S | S | S | S | S | R | NE | S | NE | S | NE | NE | S |
INH=isoniazid. RIF=rifampicin. EMB=ethambutol. PZA=pyrazinamide. SM=streptomycin. MOX=moxifloxacin. OFL=ofloxacin. AMI=amikacin. KAN=kanamycin A. CAP=capreomycin. ETH=ethionamide. PTH=prothionamide. CS=cycloserine. PAS=para-aminosalicylic acid. BDQ=bedaquiline. DLM=delamanid. LIN=linezolid. R=resistant. S=susceptible. NE=not established.
*
A child is defined as younger than 18 years of age.
†
According to the state where the patient was first diagnosed.
‡
Qualitative result of fluorescence direct material microscopy (auramine-rhodamine staining).
§
All outbreak isolates had the pncA W68C mutation.