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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Steroids. 2017 Nov 21;133:8–14. doi: 10.1016/j.steroids.2017.11.007

Figure 1.

Figure 1

Schematic of Mediator. A. Model of individual subunits in Mediator based on the structures in S. pombe and in S. cerevisiae. B. Mediator bridges transcription factors at enhancers and Pol II at the promoter. Contacts with GTFs cover much of the surface of pol II. Contacts with Mediator dominate the surface of Rpb1, the largest subunit of pol II, from which emanate the RNA transcript and the CTD. Contacts between Mediator and the unphosphorylated CTD of Pol II bring Pol II to and stabilize it at the promoter.