Table 3.
Tests of the effects of potential predictors of relative LTL as baseline covariates or moderators of the effect of time in extended and exploratory mixed models of relative LTL over time, in people with and without MDD diagnoses at baseline.
| Model | Effect | Num DF |
Den DF |
F Value |
Pr > F |
|---|---|---|---|---|---|
| Model 1: Simple | |||||
| Baseline MDD (MDD_0) | 1 | 115 | 3.19 | 0.08 | |
| Time | 1 | 115 | 0.11 | 0.74 | |
| Time*MDD_0 | 1 | 115 | 5.14 | 0.03 | |
| Model 2: Adjusted by age, gender, and baseline BMI | |||||
| Baseline MDD (MDD_0) | 1 | 112 | 2.56 | 0.11 | |
| Time | 1 | 112 | 2.22 | 0.14 | |
| Time*MDD_0 | 1 | 112 | 4.90 | 0.03 | |
| Gender | 1 | 112 | 0.83 | 0.36 | |
| Time*Gender | 1 | 112 | 0.34 | 0.56 | |
| Age | 1 | 112 | 5.17 | 0.02 | |
| Time*Age | 1 | 112 | 3.14 | 0.08 | |
| Baseline BMI (BMI_0) | 1 | 112 | 1.54 | 0.22 | |
| Time*BMI_0 | 1 | 112 | 0.45 | 0.50 | |
| Model 3: Adjusted by age, gender, baseline BMI, and lifetime alcohol/substance use disorder at baseline | |||||
| Baseline MDD (MDD_0) | 1 | 110 | 2.05 | 0.15 | |
| Time | 1 | 110 | 0.94 | 0.34 | |
| Time*MDD_0 | 1 | 110 | 3.82 | 0.05 | |
| Gender | 1 | 110 | 0.55 | 0.46 | |
| Time*Gender | 1 | 110 | 0.51 | 0.48 | |
| Age | 1 | 110 | 4.64 | 0.03 | |
| Time*Age | 1 | 110 | 2.58 | 0.11 | |
| Baseline BMI (BMI_0) | 1 | 110 | 1.19 | 0.28 | |
| Time*BMI_0 | 1 | 110 | 0.19 | 0.66 | |
| Baseline alcohol/substance use disorder, lifetime (alc_drug_0) | 1 | 110 | 0.81 | 0.37 | |
| Time*alc_drug_0 | 1 | 110 | 1.56 | 0.21 | |
| Model 4: Adjusted by age, gender, baseline BMI, and baseline ETISR-SF total scores | |||||
| Baseline MDD (MDD_0) | 1 | 106 | 1.48 | 0.23 | |
| Time | 1 | 106 | 1.81 | 0.18 | |
| Time*MDD_0 | 1 | 106 | 3.79 | 0.05 | |
| Gender | 1 | 106 | 0.63 | 0.43 | |
| Time*Gender | 1 | 106 | 0.52 | 0.47 | |
| Age | 1 | 106 | 4.39 | 0.04 | |
| Time*Age | 1 | 106 | 2.19 | 0.14 | |
| Baseline BMI (BMI_0) | 1 | 106 | 1.94 | 0.17 | |
| Time*BMI_0 | 1 | 106 | 0.59 | 0.44 | |
| Baseline ETISR-SF total score (ETISRSF_0) | 1 | 106 | 0.02 | 0.90 | |
| Time*ETISRSF_0 | 1 | 106 | 0.32 | 0.57 | |
| Model 5: Adjusted by age, gender, baseline BMI, and TEQ total scores at baseline | |||||
| Baseline MDD (MDD_0) | 1 | 110 | 2.36 | 0.13 | |
| Time | 1 | 110 | 2.66 | 0.11 | |
| Time*MDD_0 | 1 | 110 | 4.12 | 0.04 | |
| Gender | 1 | 110 | 0.85 | 0.36 | |
| Time*Gender | 1 | 110 | 0.28 | 0.60 | |
| Age | 1 | 110 | 5.09 | 0.03 | |
| Time*Age | 1 | 110 | 3.02 | 0.09 | |
| Baseline BMI (BMI_0) | 1 | 110 | 1.81 | 0.18 | |
| Time*BMI_0 | 1 | 110 | 0.77 | 0.38 | |
| Baseline TEQ total score (bl_TEQ) | 1 | 110 | 0.21 | 0.65 | |
| Time*bl_TEQ | 1 | 110 | 0.19 | 0.67 | |
| Model 6: Adjusted by age, gender, baseline BMI, and TEQ total scores at follow-up | |||||
| Baseline MDD (MDD_0) | 1 | 98 | 2.49 | 0.12 | |
| Time | 1 | 98 | 1.83 | 0.18 | |
| Time*MDD_0 | 1 | 98 | 7.20 | 0.01 | |
| Gender | 1 | 98 | 0.67 | 0.41 | |
| Time*Gender | 1 | 98 | 1.04 | 0.31 | |
| Age | 1 | 98 | 5.02 | 0.03 | |
| Time*Age | 1 | 98 | 3.74 | 0.06 | |
| Baseline BMI (BMI_0) | 1 | 98 | 0.77 | 0.38 | |
| Time*BMI_0 | 1 | 98 | 0.24 | 0.63 | |
| Follow-up TEQ total score (fu_TEQ) | 1 | 98 | 0.04 | 0.83 | |
| Time*fu_TEQ | 1 | 98 | 0.45 | 0.50 | |
| Model 7: Adjusted by age, gender, baseline BMI, baseline ETISR-SF total scores, and TEQ total scores at baseline and follow-up | |||||
| Baseline MDD (MDD_0) | 1 | 91 | 1.63 | 0.20 | |
| Time | 1 | 91 | 1.75 | 0.19 | |
| Time*MDD_0 | 1 | 91 | 5.21 | 0.02 | |
| Gender | 1 | 91 | 0.54 | 0.46 | |
| Time*Gender | 1 | 91 | 0.99 | 0.32 | |
| Age | 1 | 91 | 4.16 | 0.04 | |
| Time*Age | 1 | 91 | 1.82 | 0.18 | |
| Baseline BMI (BMI_0) | 1 | 91 | 1.31 | 0.25 | |
| Time*BMI_0 | 1 | 91 | 0.62 | 0.43 | |
| Baseline ETISR-SF total score (ETISRSF_0) | 1 | 91 | 0.04 | 0.84 | |
| Time*ETISRSF_0 | 1 | 91 | 0.41 | 0.52 | |
| Baseline TEQ total score (bl_TEQ) | 1 | 91 | 0.40 | 0.53 | |
| Time*bl_TEQ | 1 | 91 | 0.16 | 0.69 | |
| Follow-up TEQ total score (fu_TEQ) | 1 | 93 | 0.01 | 0.92 | |
| Time*fu_TEQ | 1 | 93 | 0.71 | 0.40 | |
Note: The main effect of interest is the time by MDD interaction. Each model assesses whether the inclusion of potential confounders influences this MDD effect on LTL. Abbreviations: ETISR-SF = Early Trauma Inventory Self Report-Short Form, TEQ = Traumatic Events Questionnaire, BMI = body mass index.