Table 2. Multiple primary lung cancers (MPLC) in low-dose CT (LDCT) screening studies.
| Study | No. of screenees | No. of LDCT rounds | Subjects with screen-detected primary lung cancer (%) | No. of adenocarcinomas | Subjects with MPLC | Subjects with MPLC/subjects with screen-detected primary lung cancer (%) |
|---|---|---|---|---|---|---|
| Nawa et al. 2002 (13) | 7,956 | 1 | 40 (0.5) | 39 | 1 (synchronous) | 2.5 |
| Diederich et al. 2002 (14) | 817 | 4 | 11 (1.3) | 5 | 1 (synchronous) | 9.0 |
| Flieder et al. 2006 (15) | 2,968 | 11 | 77 (2.6) | 81 | 16 (synchronous) | 20.8 |
| Carter et al. 2007 (16) | 10,056 | 11 | 250 (2.5) | 177 | 31 (synchronous), 5 (metachronous) | 14.4 |
| Lindell et al. 2007 (17) | 1,520 | 5 | 59 (3.9) | 34 | 1 (synchronous), 1 (metachronous) | 3.4 |
| Pelosi et al. 2008 (18) | 5,202 | 3 | 89 (1.7) | 72 | 10 (synchronous) | 11.2 |
| Vazquez et al. 2009 (19) | 27,456 | 12 | 338 (1.2) | 279 | 49 (synchronous) | 14.5 |
| van Klaveren et al. 2009 (20) | 7,557 | 3 | 124 (1.6) | NA | 5 (synchronous) | 4.0 |
| Infante et al. 2009 (21) | 1,276 | 4 | 60 (4.7) | 27 | 2 (synchronous), 1 (metachronous) | 5.0 |
| Saghir et al. 2012 (22) | 4,104 | 5 | 69 (1.7) | 48 | 6 (synchronous) | 8.7 |
| Sanchez-Salcedo et al. 2015 (23) | 2,989 | 14 | 53 (1.8%) | 33 | 1 (synchronous), 6 (metachronous) | 13.2 |