Table 2.
Summary of studies involving fecal microbiota transplantation and inflammatory bowel disease
| Author, year | Method | Mode of FMT Delivery | n | Outcome |
|---|---|---|---|---|
| Borody et al., 1989 [38] | Case series | Not reported | 2 | Positive |
| Borody et al., 2003 [39] | Case series | Enema | 6 | Clinical & endoscopic remission at 1 year |
| Angelberger et al., 2013 [50] | Cohort study | Nasojejunal infusion & enema | 5 | Positive |
| Kump et al., 2013 [51] | Cohort study | Colonoscopy | 6 | Positive |
| Kunde et al., 2013 [52] | Cohort study | Enema | 10 | 33% clinical response at 1 month |
| Danman et al., 2014 [53] | Cohort study | Colonoscopy | 5 | 20% clinical response |
| Cui et al., 2015 [47] | Cohort study | Nasogastric infusion | 14 | 57% clinical improvement |
| Cui et al., 2015 [49] | Cohort study | Nasogastric infusion | 30 | 86.6% clinical remission at 30 days |
| Moayyedi et al., 2015 [39] | RCT | Enema | 65 | 24% achieved remission |
| Rossen et al., 2015 [78] | RCT | Autologous stool | 48 | No significant effect |
| Suskind et al., 2015 [46] | Cohort study | Nasogastric infusion | 9 | 78% clinical remission |
| Wei et al., 2015 [54] | Cohort study | Colonoscopy (ulcerative colitis), nasojejunal infusion | 14 | Clinical improvement |
| (Crohn’s disease) | ||||
| Paramsothy et al., 2016 [43] | RCT | Enema | 81 | 30% remission achieved |
| Uygun et al., 2017 [48] | Cohort study | Colonoscopy | 30 | 70% improved symptoms, 43.3% clinical&endoscopic remission |
FMT: Fecal microbiota transplantation; RCT: Randomized controlled trial.