Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 22;8:5075. doi: 10.1038/s41598-018-23419-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Orientin administration counteracts radiation induced thrombocytopenia in animal model. Complete Blood Count (CBC) reveals enhanced platelet reconstitution in Orientin pre and post treatment group (1 mg/kg Orientin via subcutaneous route 24 h and 3 h before radiation) at time points after 6 Gy partially ablative TBI (137Cs gamma rays) in comparison to irradiated controls. The difference noted were statistically significant at day 17, 21, 24 and 30 with *p < 0.05 and **p < 0.005 compared to irradiation alone group. All the cell counts were normalized with that of unirradiated and untreated controls (CT). Mice receiving Orientin treatment 3 h and 24 hr after 6 Gy IR also showed a nominal increase in platelets (a) at Day 21 and 24, however not statistically significant. Analysis of RBCs (b), WBCs (c) and Lymphocytes (d) revealed no significant differences between the groups. Three independent experiments were performed with at least 5 animals in each group and line graphs shown are mean ± SD of a representative experiment.