Table 3.
Univariate and multivariate analysis of overall survival in CRC patients
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender | ||||
| Female | 1 | 0.031 | 1 | 0.037 |
| Male | 1.503 (1.037, 2.177) | 1.497 (1.025, 2.186) | ||
| Age | ||||
| ≤60 | 1 | 0.747 | ||
| >60 | 1.603 (0.733,1.543) | |||
| Location | ||||
| Colon | 1 | 0.651 | ||
| Rectum | 1.093 (0.743,1.610) | |||
| Differentiation | ||||
| Well/moderate | 1 | <0.001 | 1 | <0.001 |
| Poorly | 3.654 (2.482,5.380) | 2.699 (1.811, 4.022) | ||
| Histological type | ||||
| Adenocarcinoma | 1 | 0.864 | ||
| Mucous carcinoma | 0.949 (0.521,1.727) | |||
| Preoperative CEA level (ng/mL) | ||||
| ≤5 | 1 | 0.77 | ||
| >5 | 1.057 (0.729, 1.532) | |||
| pT (invasion depth) | ||||
| T1 + T2 | 1 | 0.009 | ||
| T3 + T4 | 2.299 (1.233, 4.284) | |||
| pN (lymph node metastasis) | ||||
| N0 | 1 | <0.001 | ||
| N1–2 | 2.075 (1.430, 3.012) | |||
| pM (distant metastasis) | ||||
| M0 | 1 | <0.001 | 1 | <0.001 |
| M1 | 11.327 (7.301, 17.572) | 6.295 (3.881, 10.210) | ||
| TNM stage | ||||
| I + II | 1 | <0.001 | 1 | 0.008 |
| III + IV | 3.465 (2.334, 5.143) | 1.851 (1.179, 2.908) | ||
| NRBP1 expression | ||||
| High | 1 | 0.002 | 1 | 0.014 |
| Low | 1.810 (1.243, 2.635) | 1.622 (1.104, 2.384) | ||