Table 2.
Comparison of the TNF-α, IL-1β, and IL-6 levels in cardiac tissue of each experimental group
| Parameters | Experimental Groups | P value | ||||||
|---|---|---|---|---|---|---|---|---|
| Control median (25%-75%) | Sesame oil median (25%-75%) | CDDP median (25%- 75%) | BC median (25%-75%) | CDDP+BC median (25%-75%) | CMN median (25%-75%) | CDDP+CMN median (25%-75%) | ||
| IL-1β | 79.31 | 81.95 | 89.26 | 81.51 | 88.54 | 80.50 | 85.02 | 0.000 |
| (68.10-90.72)a | (72.43-88.51)a | (84.86-99.52)b | (68.17-89.61)a,c | (76.94-98.71)b | (73.61-95.28)a | (69.60-93.67)c | ||
| IL-6 | 59.65 | 64.40 | 74.98 | 59.74 | 62.90 | 62.57 | 58.92 | 0.000 |
| (47.60-68.60)a | (47.40-76.19)a | (52.35-99.63)b | (50.32-69.51)c | (56.57-67.00)d | (47.85-78.25)c | (50.77-69.80)d | ||
| TNF-α | 61.29 | 61.00 | 70.59 | 68.49 | 70.23 | 66.70 | 59.55 | 0.000 |
| (48.59-73.68)a | (50.34-77.04)a | (55.00-79.99)b | (52.33-83.30)b | (61.02-78.82)b | (59.43-76.91)a,b | (53.18-78.37)a | ||
CDDP - cisplatin; BC - beta-carotene; CMN - curcumin; TNF-α - tumor necrosis factor-alpha; IL-1β - interleukin-1 beta; IL-6 - interleukin-6
Data are expressed as median (min.-max.) for seven rats in each group. Kruskal-Wallis analysis was used to compare the groups. Dunn-Bonferroni test was applied for multiple comparisons. Similar letters on the same line indicate similarity between groups, whereas different letters indicate differences between groups. P<0.05 was considered significant.