Table 3.
Genotype distribution and allelic frequencies of IL1RN VNTR, IL1 β -511 (rs16944) and IL1 β +3954 (rs1143634) polymorphisms in control group and CSFP patients
| Genotype Frequencies | Controls (n=62) n, % | CSFP (n=48) n, % | Allelic Frequencies | Controls n, % | CSFP n, % |
|---|---|---|---|---|---|
| IL1RN VNTR | |||||
| 1/1 | 41, 66.1 | 31, 64.1 | Allele 1, % | 96, 77.4 | 76, 79.2 |
| 1/2 | 14, 22.6 | 13, 27.1 | Allele 2, % | 24, 19.4 | 19, 19.8 |
| 2/2 | 4, 6.5 | 3, 6.3 | Other, % | 4, 3.2 | 1, 1 |
| Other/Other | 1, 1.6 | – | |||
| 1/Other | – | 1, 2.1 | |||
| 2/Other | 2, 3.2 | – | |||
| Control/CSFP | X2=3.849; P=0.571 | X2=1.16 ;P=0.56 | |||
| IL1β-511 | |||||
| 1/1 | 26, 41.9 | 27, 56.3 | Allele 1, % | 77, 62.1 | 68, 70.8 |
| 1/2 | 25, 40.3 | 14, 29.2 | Allele 2, % | 47, 37.9 | 28, 29.2 |
| 2/2 | 11, 17.7 | 7, 14.6 | |||
| Control/CSFP | X2=2.26; P=0.32 | X2=1.83; P=0.17 | |||
| IL1β+3954 | |||||
| 1/1 | 31, 50.0 | 19, 39.6 | Allele 1, % | 84, 71.4 | 50, 52.1 |
| 1/2 | 22, 35.5 | 12, 25 | Allele 2, % | 40, 28.6 | 46, 47.9 |
| 2/2 | 9, 14.5 | 17, 35.4 | |||
| Control/CSFP | X2= 6.6; P=0.04 | X2=5.6; P=0.02 | |||
Pearson’s X2 test was used for testing for Hardy-Weinberg equilibrium in distribution of genetic polymorphisms.
CSFP-Coronary slow flow phenomenon; IL-1RN VNTR Interleukin-1 receptor antagonist gene variable number tandem repeat; IL1β-511 (rs16944), Interleukin-1β polymorphisms in-511 position; IL1β+3954 (rs1143634), Interleukin-1β polymorphisms in+3954 position.