Table 6.

Individual questions of FACT-AntiA (Version 4) questionnaire in the entire study cohort.

Question	Screening	End of follow up	p-value
I feel fatigued	2 [1.75; 2.25]	1 [0.75; 2]	0.016
I feel weak all over	1.5 [1; 2.25]	1 [1; 2]	0.258
My fatigue keeps me from doing the things I want to do	1 [0; 2]	1 [0; 1]	0.109
I am bothered by mouth sores or tenderness	2 [0.75; 2.25]	1 [0.75; 1.25]	0.063
Because of my mouth sores. Eating is difficult	1 [0; 2.25]	0 [0; 0.25]	0.063
The skin on my hands hurts	0.5 [0; 2.25]	0 [0; 0]	0.063
Hand pain or tenderness interferes with my daily activities	1 [0; 3.25]	0 [0; 1]	0.047
The skin on my feet hurts	0.5 [0; 3]	0 [0; 1]	0.031
Pain on the bottom of my feet interferes with my walking	1.5 [1; 3.25]	1 [0; 2.25]	0.297
I have diarrhea (diarrhoea)	2 [0; 3.25]	1 [0; 2]	0.188
I have to limit my activities because of diarrhea (diarrhoea)	1 [0; 2]	1 [0; 1]	0.344
I am bothered by a change in the way food tastes	1 [0; 1.25]	0.5 [0; 1]	0.156
I am bothered by dry mouth	3.5 [1.75; 4]	1 [1; 3]	0.047
I am bothered by headaches	3 [1.75; 3]	1 [0; 2]	0.004
I have pain in my joints	0 [0; 1.5]	0 [0; 0.25]	0.375
I am bothered by constipation	1 [0; 3]	1 [0; 2]	0.094
I am bothered by a skin rash	1.5 [0; 2.25]	0 [0; 1]	0.031
I am bothered by nosebleeds	2 [1.75; 3.25]	0.5 [0; 1.25]	0.007
I am bothered by hair loss	0 [0; 2.25]	0 [0; 0.25]	0.156
I am bothered by swelling in certain areas of my body	0 [0; 1]	0 [0; 0]	0.125
I have a loss of appetite	1 [0; 1.25]	0 [0; 1]	0.344
I have been short of breath	1 [0; 2.25]	0 [0; 0.25]	0.063
I have been vomiting	0 [0; 2]	0 [0; 0]	0.125

Data are expressed as median [25th; 75th percentile].