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. 2018 Mar 22;8:5025. doi: 10.1038/s41598-018-23298-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Insulin increases the transcriptional activity of SF-1. Dose-dependent effect of insulin on SF-1 transcription in HEK293 cells (a). Increase in Cyp11b1 transcriptional activity by time-dependent insulin treatment after co-transfection of SF-1 (b). Relative luciferase activity of Cyp11b1 after insulin treatment in Y1 cells (c). Effect of insulin on SF-1 and steroidogenic genes after knocking down SF-1 (d and e). The values are mean ± SEM (*p < 0.05, Student’s t-test, one-way ANOVA). EV, empty vector. SF-1-Luc, SF-1 luciferase construct. Cyp11b1-Lu, Cyp11b1 luciferase construct.