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. 2018 Mar 16;5:58. doi: 10.3389/fmed.2018.00058

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Copyright © 2018 Ochs, Meili, Diebold, Arndt and Günthert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trends in age-standardized incidence of cervical cancer (CC) and CIN3 in conizations in Central Switzerland, 2000–2014. There is a trend toward increasing age-standardized incidence rates (ASIR) of CC (p-value 0.075) and a significant increase of ASIR of CIN3 (p-value < 0.001). There is no significant increase of ASIR of squamous cell carcinoma (SCC) from 1.8/100,000 between 2000 and 2004 to 2.4/100,000 between 2005 and 2009 and between 2010 and 2014 (p-value 0.132) and of adenocarcinoma (AC) from 0.4/100,000 between 2000 and 2004 to 0.6/100,000 between 2005 and 2009 to 0.9/100,000 between 2010 and 2014 (p-value 0.423).