Table 1.

Prognostic clinicopathologic variables as predictors of disease-specific survival in 335 NSCLC-patients.

Characteristics	Patients N, (% of total)	Median survival (months)	5-year survival (%)	P
Age				0.42
≤65 years	156 (47)	98	56
>65 years	179 (53)	NR	60
Sex				0.22
Female	82 (24)	190	64
Male	253 (76)	98	56
Smoking status				0.26
Never	15 (5)	19	43
Previous	105 (31)	84	55
Present	215 (64)	NR	60
Performance status				0.016
0	197 (59)	NR	63
1	120 (36)	64	52
2	18 (5)	25	33
Weight loss				0.76
<10%	303 (90)	190	58
>10%	32 (10)	98	57
Histology				0.028
Squamous cell carcinoma	191 (57)	NR	66
Adenocarcinoma	113 (34)	54	46
Large cell carcinoma	31 (9)	98	56
Differentiation				<0.001
Poor	138 (41)	47	47
Moderate	144 (43)	190	65
Well	53 (16)	NR	68
Surgical procedure				0.007
Wedge + Lobectomy	243 (73)	190	62
Pneumectomy	92 (27)	37	47
pStage				<0.001
pI	157 (47)	NR	72
pII	136 (41)	62	51
pIIIA	42 (12)	17	24
pT-status				<0.001
1	85 (25)	190	75
2	188 (56)	84	57
3	62 (19)	25	37
pN-status				<0.001
0	232 (69)	NR	67
1	76 (23)	35	43
2	27 (8)	18	18
Surgical margins				0.37
Free	307 (92)	190	59
Not free	28 (8)	47	48
Vascular infiltration				<0.001
No	284 (85)	190	62
Yes	51 (15)	27	33
Pax6 expression	335 (100)			0.10
High	94 (28)	NR	67
Low	241 (72)	75	55
Pax6 expression in AC	113 (34)			0.32
High	22 (7)	NR	57
Low	91 (27)	47	44
Pax6 expression in SCC	191 (57)			0.52
High	60 (18)	NR	73
Low	131 (39)	NR	63
Pax6 expression in pN+	103 (31)			0.022
High	33 (10)	127	59
Low	70 (21)	23	26

AC – adenocarcinoma, NR – not reached, SCC – squamous cell carcinoma.