Table 2.
Comparison of NKX2-5 variant rate across diverse populations with non-syndromic secundum atrial septal defect
| Region | Population reference | Study reference | NKX2-5 variant frequency in ASD patients (%) | P* |
|---|---|---|---|---|
| North Africa and Middle East | Lebanese | Abou Hassan et al. 2015 (45) | 6/25 (24) | 0.16 |
| Egyptian | Hussein et al. 2009 (46) | 2/8 (25) | 0.25 | |
| Europe | German | Stallmeyer et al. 2010 (12) | 2/17 (11.7) | 1 |
| Italian | Sarkozy et al. 2005 (47) | 3/29 (10.3) | 1 | |
| America and Australia | American | McElhinney et al. 2003 (15) | 3/71 (4.2) | 0.37 |
| Australian/American | Elliott et al. 2003 (14) | 1/102 (0.9) | 0.04 | |
| Asia | Chinese (Yunnan) | Yu Cao et al. 2016 (48) | 0/105 (0) | 0.01 |
| Chinese (Han) | Liu et al. 2011 (49) | 3/58 (5.17) | 0.66 | |
| Japanese | Hirayama-Yamada et al. 2005 (50) | 3/16 (18.7) | 0.38 | |
| Morocco | Moroccan | Present study | 3/32 (9.4) | – |
*
Compared to present study rate using Fisher’s exact test