Table 3. Increase in serum lipid levels with an increase of alcohol intake by 10 g/day according to the genotypes of ADH1B and ALDH2 in the main studya.
| Loge-triglycerides (mg/dL) | Loge-HDL cholesterol (mg/dL) | LDL cholesterol (mg/dL) | |||||||
| n | β | (95% Cl) | n | β | (95% Cl) | n | β | (95% Cl) | |
| All | 889 | 0.006 | (−0.006 to 0.018) | 889 | 0.024 | (0.019–0.030) | 872 | −1.47 | (−2.20 to −0.75) |
| Genotypes | |||||||||
| ADH1B (rs1229984) | |||||||||
| His/His | 517 | 0.017 | (0.001–0.032) | 517 | 0.024 | (0.017–0.032) | 508 | −1.59 | (−2.56 to −0.62) |
| P for interaction | reference | reference | reference | ||||||
| His/Arg or Arg/Arg | 372 | −0.005 | (−0.024 to 0.014) | 372 | 0.025 | (0.016–0.033) | 364 | −1.30 | (−2.40 to −0.19) |
| P for interaction | 0.020 | 0.609 | 0.871 | ||||||
| ALDH2 (rs671) | |||||||||
| Glu/Glu | 482 | 0.002 | (−0.014 to 0.018) | 482 | 0.025 | (0.017–0.032) | 470 | −0.73 | (−1.72 to 0.25) |
| P for interaction | reference | reference | reference | ||||||
| Glu/Lys or Lys/Lys | 407 | 0.004 | (−0.019 to 0.027) | 407 | 0.021 | (0.010–0.032) | 402 | −2.49 | (−3.85 to −1.13) |
| P for interaction | 0.772 | 0.667 | 0.006 | ||||||
CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
aDetermined by linear regression analysis adjusted for age, physical activity, body mass index, energy intake, study area, education, diabetes and smoking status as covariates.